Search results for "kinetic models"
showing 7 items of 7 documents
Thermodynamic and Kinetic Modeling of Co-utilization of Glucose and Xylose for 2,3-BDO Production by Zymomonas mobilis
2021
Prior engineering of the ethanologen Zymomonas mobilis has enabled it to metabolize xylose and to produce 2,3-butanediol (2,3-BDO) as a dominant fermentation product. When co-fermenting with xylose, glucose is preferentially utilized, even though xylose metabolism generates ATP more efficiently during 2,3-BDO production on a BDO-mol basis. To gain a deeper understanding of Z. mobilis metabolism, we first estimated the kinetic parameters of the glucose facilitator protein of Z. mobilis by fitting a kinetic uptake model, which shows that the maximum transport capacity of glucose is seven times higher than that of xylose, and glucose is six times more affinitive to the transporter than xylose.…
Review of Pharmacokinetics and Pharmacogenetics in Atypical Long-Acting Injectable Antipsychotics
2021
Over the last two decades, pharmacogenetics and pharmacokinetics have been increasingly used in clinical practice in Psychiatry due to the high variability regarding response and side effects of antipsychotic drugs. Specifically, long-acting injectable (LAI) antipsychotics have different pharmacokinetic profile than oral formulations due to their sustained release characteristics. In addition, most of these drugs are metabolized by CYP2D6, whose interindividual genetic variability results in different metabolizer status and, consequently, into different plasma concentrations of the drugs. In this context, there is consistent evidence which supports the use of therapeutic drug monitoring (TD…
Multicomponent Antibiofilm Lipid Nanoparticles as Novel Platform to Ameliorate Resveratrol Properties: Preliminary Outcomes on Fibroblast Proliferati…
2023
The well-being of skin and mucous membranes is fundamental for the homeostasis of the body and thus it is imperative to treat any lesion quickly and correctly. In this view, polyphenols might assist and enhance a successful wound healing process by reducing the inflammatory cascade and the production of free radicals. However, they suffer from disadvantageous physico–chemical properties, leading to restricted clinical use. In this work, a complex mixture of PEGylated lipid, Glyceryl monoester, 18-β-Glycyrrhetinic Acid and Menthol was designed to entrap Resveratrol (RSV) as the active ingredient and further produce lipid nanoparticles (LNPs) by homogenization followed by high-freq…
Role of Vibrational Dynamics in Electronic Relaxation of Cr(acac)3
2015
Ultrafast energy relaxation of Cr(acac)3 dissolved in tetrachloroethylene (TCE) is studied by time-resolved infrared (TRIR) spectroscopy by using electronic and vibrational excitation. After electronic excitation at 400 or 345 nm, the ground state recovers in two time scales: 15 ps (major pathway) and 800 ps (minor pathway), corresponding to fast electronic transition to the ground state and intermediate trapping on the long-lived (2)E state followed by intersystem crossing (ISC) to the ground state. The quantum yield for the fast recovery of the ground state depends on the excitation wavelength, being higher for 345 nm. Vibrational cooling (VC) occurs on the electronic excited states with …
Catalytic cracking of n-alkane naphtha: The impact of olefin addition and active sites differentiation
2015
An extended dual kinetic model allows to fit the n-heptane cracking results working in a wide range of reaction conditions. The duality of the model is provided by the contribution of monomolecular and bimolecular cracking mechanisms. It takes into account the role played by the olefins formed on the global cracking or added within the feed. Furthermore by means of this model and the kinetic parameters obtained when cracking n-heptane on ZSM-5, it has been observed that, while some characterization techniques show a homogeneous zeolite surface from the point of view of the active sites, rigorous kinetic experiments point to the possibility that the reactant sees a heterogeneous surface with…
Removal of ammonium ions from aqueous solutions using alkali-activated analcime as sorbent
2023
Five alkali-activated analcime (ANA) sorbents (ANA-MK 1, ANA 2, ANA 3, ANA-MK 4, and ANA-MK 5) were developed for ammonium (NH4+) ion removal. Acid treatment and calcination were used as pre-treatments for analcime, and metakaolin (MK) was used as a blending agent in three sorbents. Sorption experiments were performed to evaluate the effects of sorbent dosage (1–20 g L−1), initial NH4+ ion concentration (5–1000 g L−1), and contact time (1 min–24 h). ANA-MK 1, ANA 2, and ANA-MK 4 were the most efficient sorbents for NH4+ ion removal, with a maximum experimental sorption uptake of 29.79, 26.00, and 22.24 mg g−1, respectively. ANA 3 and ANA-MK 5 demonstrated…
Alkali-Activated Adsorbents from Slags: Column Adsorption and Regeneration Study for Nickel(II) Removal
2021
Alkali-activated adsorbents were synthesized by mixing three different slags from the steel industry: blast furnace slag (BFS), ladle slag (LS), and Lintz–Donawitz converter slag (LD). These powdered slag-based geopolymers (GP) were used to remove nickel(II) from aqueous solutions in fixed-bed column studies. The experiments were conducted in pH 6 using a phosphate buffer with initial nickel(II) concentration of 50 mg/L. Samples were taken at time intervals of between 5 and 90 min. Three adsorption–desorption cycles were implemented with a flow rate of 5 mL/min. The geopolymers were characterized by Fourier-Transform Infrared Spectroscopy (FTIR), X-ray powder diffraction (XRD), Field Emissi…